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Vortrag von Anna Ziegler

Vortragstitel: "Lipids - Architects of the developing brain"
Anlass: SFB - Seminar
Beginn: 20.11.2025, 16:15 Uhr
Ort: CellNanOs, 38/201

Über die Vortragende: Dr. Anna Ziegler forscht am Institut für Neurobiologie und Verhaltensbiologie an der Universität Münster.

The brain is a fat-rich organ. A deregulated lipid homeostasis not only leads to developmental disorders but also to premature death of nerve cells. However, little is known about the regulation of fat metabolism in the brain, especially during development. We therefore investigate changes in the lipidome during brain development using fruit flies as a model organism. Particularly striking here are a sharp increase in triglycerides (TAGs) during the larval stages and subsequent decline during the pupal stages. As TAGs are predominantly stored in lipid droplets, we are currently investigating how the absence of these TAG rich lipid droplets affects the development of the nervous system. In addition, we are investigating how the absence or deregulation of lipids that occur in low concentrations, such as certain sphingolipids, affects nerve cell development and maintenance. To do so, we are using a combination of genetics, histology, mass- spectrometry and a click-chemistry based approach for metabolic tracing of lipids.