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Vortrag von Sven Thoms
Vortragstitel: "A big heart for peroxisomes"
Anlass: SFB Seminar
Host: Christian Ungermann
Beginn: 27.01.2022 - 16:15
Ort: CellNanOs 38/201 und online. Für die Zugangsdaten wenden Sie sich bitte ans SFB-Büro.
Über den Vortragenden: Der Vortragende leitet die Arbeitsgruppe Biochemie und Molekulare Medizin an der Medizinischen Fakultät OWL, Universität Bielefeld.
Inhalt des Vortrags: A couple of years ago, we co-discovered a new gene-regulatory mechanism: Endogenous translational readthrough (stop codon suppression) leads to the expression of ‘extended’ forms of lactate dehydrogenase and malate dehydrogenase. The extensions carry targeting signals for the peroxisome, so that a fraction of these enzymes is imported into peroxisomes, giving rise to a – hypothetical – metabolite shuttle at the peroxisomal membrane [1–3]. In the first part of the talk I will present this discovery; in the second part I will turn to our recent and unpublished work on how we use mouse models and human induced pluripotent stem cells to study the role of peroxisomes in the heart.
